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Article

Pathoadaptive mutations that enhance virulence: genetic organization of the cadA regions of Shigella spp.

Infection and immunity - 1 Dec 2001

Day W A, Fernández R E, Maurelli A T

Abstract excerpt

Pathoadaptive mutations improve the fitness of pathogenic species by modification of traits that interfere with factors (virulence and ancestral) required for survival in host tissues. A demonstrated pathoadaptive mutation is the loss of lysine decarboxylase (LDC) expression in Shigella species that have evolved from LDC-expressing Escherichia coli. Previous studies demonstrated that the product of LDC activity,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11705922
DOI: 10.1128/IAI.69.12.7471-7480.2001
PMCID: PMC98836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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