Article
AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.
Scientific reports - 21 Nov 2013
Yagi Hirokazu, Nakagawa Naoki, Saito Takuya, Kiyonari Hiroshi, Abe Takaya, Toda Tatsushi, Wu Sz-Wei, Khoo Kay-Hooi, Oka Shogo, Kato Koichi
Abstract excerpt
Dystroglycanopathy is a major class of congenital muscular dystrophy that is caused by a deficiency of functional glycans on α-dystroglycan (α-DG) with laminin-binding activity. A product of a recently identified causative gene for dystroglycanopathy, AGO61, acted in vitro as a protein O-mannose β-1, 4-N-acetylglucosaminyltransferase, although it was not functionally characterized. Here we show the phenotypes of...
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