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Article

Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expression

9 Feb 2015

Abstract excerpt

α-Dystroglycanopathy (α-DGP) is a group of muscular dystrophy characterized by abnormal glycosylation of α-dystroglycan (α-DG), including Fukuyama congenital muscular dystrophy (FCMD), muscle-eye-brain disease, Walker-Warburg syndrome, and congenital muscular dystrophy type 1D (MDC1D), etc. LARGE, the causative gene for MDC1D, encodes a glycosyltransferase to form [-3Xyl-α1,3GlcAβ1-] polymer in the terminal end...

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PMID: 25661440
DOI: 10.1038/srep08316

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Fukutin is prerequisite to ameliorate muscular dystrophic phenotype by myofiber-selective LARGE expressionPMID 25661440Read ↗

Adeno-associated viral-mediated LARGE gene therapy rescues the muscular dystrophic phenotype in mouse models of dystroglycanopathy.Semantic proximity Read ↗

Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein.Semantic proximity Read ↗

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<i>Large1</i> Gene Transfer in Older <i>myd</i> Mice with Severe Muscular Dystrophy Restores Muscle Function and Greatly Improves SurvivalSemantic proximity Read ↗

The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice.Semantic proximity Read ↗

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