Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice

doi:10.1111/j.1699-0463.1997.tb05092.x

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Article

Chronic Pseudomonas aeruginosa lung infection is more severe in Th2 responding BALB/c mice compared to Th1 responding C3H/HeN mice

1 Jul 1997

Abstract excerpt

The chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) is characterized by a pronounced antibody response and microcolonies surrounded by numerous polymorphonuclear neutrophils (PMN). Poor prognosis is correlated with a high antibody response to P. aeruginosa antigens. An animal model of this infection was established in two strains of mice: C3H/HeN and BALB/c, generally known as Th1 and Th2...

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PMID: 9393554
DOI: 10.1111/j.1699-0463.1997.tb05092.x

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Chronic <i>Pseudomonas aeruginosa</i> lung infection is more severe in Th<sub>2</sub> responding BALB/c mice compared to Th<sub>1</sub> responding C<sub>3</sub>H/HeN mice

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