Article
Lack of association of common cystic fibrosis transmembrane conductance regulator gene mutations with primary sclerosing cholangitis.
The American journal of gastroenterology - 1 Apr 2005
Gallegos-Orozco Juan F, E Yurk Catherine, Wang Nulang, Rakela Jorge, Charlton Michael R, Cutting Garry R, Balan Vijayan
Abstract excerpt
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease of uncertain etiology. However, the histologic features of PSC liver disease can resemble those in cystic fibrosis (CF), an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. We sought to determine if PSC patients have a higher frequency of common CF alleles than...
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