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Article

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.

Oncogene - 19 May 2005

Edwards Lincoln A, Thiessen B, Dragowska Wieslawa H, Daynard Tim, Bally Marcel B, Dedhar Shoukat

Abstract excerpt

The tumor suppressor gene phosphatase and tensin homologue (PTEN) regulates the phosphatidylinositol-3'-kinase (PI3K) signaling pathway and has been shown to correlate with poor prognosis in high-grade astrocytomas when mutational inactivation or loss of the PTEN gene occurs. PTEN mutation leads to constitutive activation of protein kinase B (PKB)/Akt with phosphorylation at the PKB/Akt sites Thr-308 and Ser-473....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15782140
DOI: 10.1038/sj.onc.1208427

Genes

PTEN
ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.PMID 15782140Read ↗

PI3K Signaling in Glioma—Animal Models and Therapeutic ChallengesSemantic proximity Read ↗

Targeting the AKT Pathway in GlioblastomaSemantic proximity Read ↗

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaSemantic proximity Read ↗

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.Semantic proximity Read ↗

Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent miceSemantic proximity Read ↗

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.Semantic proximity Read ↗

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.Semantic proximity Read ↗

Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.Semantic proximity Read ↗

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell lineSemantic proximity Read ↗

Nonredundant Functions for Akt Isoforms in Astrocyte Growth and Gliomagenesis in an Orthotopic Transplantation ModelSemantic proximity Read ↗

mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.Semantic proximity Read ↗

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.Semantic proximity Read ↗

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