Article
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Current biology : CB - 22 Oct 1998
Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D
Abstract excerpt
Glioblastomas are highly malignant tumors of the central nervous system that are resistant to radiation and chemotherapy [1]. We explored the role of the phosphatidylinositol (PI) 3-kinase signal transduction pathway in glioblastomas, as this pathway has been shown to inhibit apoptosis induced by...
Topics
- 3-Phosphoinositide-Dependent Protein Kinases
- 3T3 Cells
- Animals
- Astrocytes
- COS Cells
- Enzyme Activation
- Genes, Tumor Suppressor
- Glioblastoma
- Humans
- Mice
- Mutation
- PTEN Phosphohydrolase
- Phosphatidylinositol 3-Kinases
- Phosphatidylinositol Phosphates
- Phospholipids
- Phosphoric Monoester Hydrolases
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases