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Article

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

Current biology : CB - 22 Oct 1998

Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D

Abstract excerpt

Glioblastomas are highly malignant tumors of the central nervous system that are resistant to radiation and chemotherapy [1]. We explored the role of the phosphatidylinositol (PI) 3-kinase signal transduction pathway in glioblastomas, as this pathway has been shown to inhibit apoptosis induced by cytokine withdrawal and the detachment of cells from the extracellular matrix [2]. Components of this pathway have...

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Source

Identifiers

PMID: 9799739
DOI: 10.1016/s0960-9822(07)00493-9

Genes

PTEN
PDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.PMID 9799739Read ↗

PI3K Signaling in Glioma—Animal Models and Therapeutic ChallengesSemantic proximity Read ↗

PI3K/Akt and Stat3 signaling regulated by PTEN control of the cancer stem cell population, proliferation and senescence in a glioblastoma cell lineSemantic proximity Read ↗

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells.Semantic proximity Read ↗

PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastomaSemantic proximity Read ↗

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.Semantic proximity Read ↗

PI3Kinase signaling in glioblastoma.Semantic proximity Read ↗

Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.Semantic proximity Read ↗

Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.Semantic proximity Read ↗

Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.Semantic proximity Read ↗

Could changes in the regulation of the PI3K/PKB/Akt signaling pathway and cell cycle be involved in astrocytic tumor pathogenesis and progression?Semantic proximity Read ↗

PIK3CA alterations in primary (de novo) and secondary glioblastomas.Semantic proximity Read ↗

Loss of PTEN expression leading to high Akt activation in human multiple myelomasSemantic proximity Read ↗

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