Article
Phenotypic characterization of telomerase-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell lines.
Experimental cell research - 1 Apr 2006
Gu Yongpeng, Li Hongzhen, Miki Jun, Kim Kee-Hong, Furusato Bungo, Sesterhenn Isabell A, Chu Wei-Sing, McLeod David G, Srivastava Shiv, Ewing Charles M, Isaacs William B, Rhim Johng S
Abstract excerpt
In vitro human prostate cell culture models are critical for clarifying the mechanism of prostate cancer progression and for testing preventive and therapeutic agents. Cell lines ideal for the study of human primary prostate tumors would be those derived from spontaneously immortalized tumor cells; unfortunately, explanted primary prostate cells survive only short-term in culture, and rarely immortalize...
Topics
- Adult
- Aged
- Animals
- Cell Aggregation
- Cell Proliferation
- Chromosomes, Human
- Cytogenetic Analysis
- DNA-Binding Proteins
- Dihydrotestosterone
- Gene Expression Profiling