Article
C-Myc-independent restoration of multiple phenotypes by two C-Myc target genes with overlapping functions.
Cancer research - 15 Mar 2005
Rothermund Krisiti, Rogulski Kenneth, Fernandes Elaine, Whiting Amy, Sedivy John, Pu Lixia, Prochownik Edward V
Abstract excerpt
C-MYC, a transforming oncogene that is frequently overexpressed in many human cancers, regulates a variety of normal functions including cell cycle progression, apoptosis, and maintenance of cell size, morphology, and genomic integrity. Many target genes are modulated by c-Myc, and some can recapitulate a limited number of the above functions. Because most of these have been assessed in cells which also express...
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