Article
Deregulation of common genes by c-Myc and its direct target, MT-MC1.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2005
Rogulski Kenneth R, Cohen Debra E, Corcoran David L, Benos Panayiotis V, Prochownik Edward V
Abstract excerpt
In addition to its role in cancer, the c-Myc oncoprotein controls many normal cellular processes as a consequence of its function as a basic helix-loop-helix leucine zipper transcription factor. Determining which of the myriad genes under c-Myc control are relevant for these various roles is thus a major challenge. mt-mc1 is a direct c-Myc target gene whose overexpression recapitulates multiple c-Myc phenotypes,...
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