Article
Mapping and binding analysis of peptides derived from the tumor-associated antigen survivin for eight HLA alleles.
Cancer immunity - 22 Mar 2005
Bachinsky Margaret M, Guillen Darlene E, Patel Sima R, Singleton Judith, Chen Chaoyuan, Soltis Daniel A, Tussey Lynda G
Abstract excerpt
There is considerable interest in developing immunotherapeutic approaches to elicit tumor-specific CTL responses in cancer patients. Epitope-based approaches aim to deliver the antigenic peptides or epitopes recognized by CTLs rather than the intact tumor antigen. Many tumor-associated proteins are nonmutated self proteins for which the dominant peptide epitopes are usually poorly immunogenic. The subdominant...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.