Article
HLA-B35-restricted immune responses against survivin in cancer patients.
International journal of cancer - 1 Mar 2004
Reker Sine, Becker Jürgen C, Svane Inge Marie, Ralfkiaer Elisabeth, Straten Per-thor, Andersen Mads Hald
Abstract excerpt
Two HLA-A2 restricted epitopes have recently been identified from the broadly expressed tumor antigen survivin, and several vaccination trials in cancer patients based on these survivin-derived peptides have been initiated. Consequently, there is a crucial need for the identification of survivin epitopes restricted to other HLA-molecules in order to extend the proportion of patients that can enter these ongoing...
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