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Article

14-3-3: A Case Study in PPI Modulation

8 Jun 2018

Abstract excerpt

In recent years, targeting the complex network of protein⁻protein interactions (PPIs) has been identified as a promising drug-discovery approach to develop new therapeutic strategies. 14-3-3 is a family of eukaryotic conserved regulatory proteins which are of high interest as potential targets for pharmacological intervention in human diseases, such as cancer and neurodegenerative and metabolic disorders. This...

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PMID: 29890630
DOI: 10.3390/molecules23061386

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