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Article

Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling.

Molecular and cellular biology - 1 Jul 2002

Bao Wenjie, Thullberg Minna, Zhang Hongquan, Onischenko Anatoli, Strömblad Staffan

Abstract excerpt

The cyclin-dependent kinase 2 (Cdk2) inhibitors p21(CIP1) and p27(KIP1) are negatively regulated by anchorage during cell proliferation, but it is unclear how integrin signaling may affect these Cdk2 inhibitors. Here, we demonstrate that integrin ligation led to rapid reduction of p21(CIP1) and p27(KIP1) protein levels in three distinct cell types upon attachment to various extracellular matrix (ECM) proteins,...

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Identifiers

PMID: 12052868
DOI: 10.1128/MCB.22.13.4587-4597.2002
PMCID: PMC133897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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