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Article

Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter.

Gene - 28 Mar 2005

Zhang Qingbei, Pedigo Nancy, Shenoy Satyendra, Khalili Kamel, Kaetzel David M

Abstract excerpt

Transcription of the PDGF-A chain gene is regulated by multiple promoter and silencer elements that are GC-rich and exhibit considerable single-stranded character. In this study, the 42 kDa single-stranded DNA and RNA binding protein, Puralpha, was investigated with respect to its ability to bind and interact functionally with single-stranded DNA elements in the PDGF-A gene. Recombinant GST-Puralpha bound with...

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Identifiers

PMID: 15777709
DOI: 10.1016/j.gene.2004.12.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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