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Article

Puralpha, a single-stranded deoxyribonucleic acid binding protein, augments placental lactogen gene transcription.

Molecular endocrinology (Baltimore, Md.) - 1 Feb 2004

Limesand Sean W, Jeckel Kimberly M, Anthony Russell V

Abstract excerpt

Placental lactogen (PL) is thought to alter maternal metabolism to increase the pool of nutrients available for the fetus and to stimulate fetal nutrient uptake. The ovine (o) PL gene is expressed in chorionic binucleate cells (oBNC) and cis-elements located within the proximal promoter (-124 to +16 bp) are capable of trophoblast-specific expression in human (BeWo) and rat (Rcho-1) choriocarcinoma cells....

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PMID: 14645500
DOI: 10.1210/me.2003-0392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Puralpha, a single-stranded deoxyribonucleic acid binding protein, augments placental lactogen gene transcription.PMID 14645500Read ↗

Rcho-1 trophoblast cell placental lactogens: complementary deoxyribonucleic acids, heterologous expression, and biological activities.Semantic proximity Read ↗

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Puralpha activates PDGF-A gene transcription via interactions with a G-rich, single-stranded region of the promoter.Semantic proximity Read ↗

Specificity protein-1 and -3 trans-activate the ovine placental lactogen gene promoter.Semantic proximity Read ↗

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Identification of a placental-specific enhancer in the rat placental lactogen II gene that contains binding sites for members of the Ets and AP-1 (activator protein 1) families of transcription factors.Semantic proximity Read ↗

Mechanism of DNA binding and localized strand separation by Pur alpha and comparison with Pur family member, Pur beta.Semantic proximity Read ↗

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