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Article

Interleukin-10 genotypes are associated with systemic sclerosis and influence disease-associated autoimmune responses.

Genes and immunity - 1 May 2005

Hudson L L, Rocca K M, Kuwana M, Pandey J P

Abstract excerpt

Systemic sclerosis (SSc; scleroderma) is a connective tissue disease, characterized by fibrotic, immunological, and vascular abnormalities. Interleukin-10 (IL-10) is an anti-inflammatory cytokine that modulates collagen production and B-cell survival. To determine if certain IL-10 genotypes are risk factors for the development of SSc and influence disease-associated autoimmune responses, 248 Caucasian and 264...

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PMID: 15772682
DOI: 10.1038/sj.gene.6364180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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