Article
Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.
Genes & development - 15 Mar 2005
Vries Robert G J, Bezrookove Vladimir, Zuijderduijn Lobke M P, Kia Sima Kheradmand, Houweling Ada, Oruetxebarria Igor, Raap Anton K, Verrijzer C Peter
Abstract excerpt
The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs). Here, we report that loss of hSNF5 function in MRT-derived cells leads to polyploidization and chromosomal instability. Re-expression of hSNF5 restored the coupling between cell cycle progression and ploidy checkpoints. In contrast, cancer-associated hSNF5...
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