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Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2005

Shike Toshihide, Gohda Tomohito, Tanimoto Mitsuo, Kobayashi Michimasa, Makita Yuichiro, Funabiki Kazuhiko, Horikoshi Satoshi, Hirose Sachiko, Shirai Toshikazu, Tomino Yasuhiko

Abstract excerpt

BACKGROUND: The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. We previously reported a genome-wide linkage analysis of KK/Ta alleles contributing to type 2 diabetes and related phenotypes such as fasting hyperglycaemia, glucose intolerance, hyperinsulinaemia, obesity and dyslipidaemia. METHODS: Since KK/Ta mice spontaneously develop renal lesions closely resembling those in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15769825
DOI: 10.1093/ndt/gfh665

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