Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model.

Diabetes - 1 Aug 2001

Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y

Abstract excerpt

The KK/Ta mouse strain serves as a suitable polygenic model for human type 2 diabetes. Using 93 microsatellite markers in 208 KK/Ta x (BALB/c x KK/Ta)F1 male backcross mice, we carried out a genome-wide linkage analysis of KK/Ta alleles contributing to type 2 diabetes and related phenotypes, such as obesity and dyslipidemia. We identified three major chromosomal intervals significantly contributing to impaired...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Glucose
Share to Body Weight
Share to Cholesterol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crosses, Genetic

Share to Insulin

Share to Mice, Inbred BALB C

Share to Mice, Inbred Strains

Share to Triglycerides

Source

Identifiers

PMID: 11473059
DOI: 10.2337/diabetes.50.8.1943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model.PMID 11473059Read ↗

Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice.Semantic proximity Read ↗

Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice.Semantic proximity Read ↗

Identification of quantitative trait loci for diabetic nephropathy in KK-Ay/Ta mice.Semantic proximity Read ↗

Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation.Semantic proximity Read ↗

Quantitative trait loci that regulate plasma lipid concentration in hereditary obese KK and KK-Ay mice.Semantic proximity Read ↗

M-cadherin, a candidate gene for type 2 diabetes and related phenotypes in a KK/Ta mouse model.Semantic proximity Read ↗

Identification of epistatic interaction involved in obesity using the KK/Ta mouse as a Type 2 diabetes model: is Zn-alpha2 glycoprotein-1 a candidate gene for obesity?Semantic proximity Read ↗

Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice.Semantic proximity Read ↗

Knockout Mice Challenge our Concepts of Glucose Homeostasis and the Pathogenesis of DiabetesSemantic proximity Read ↗

Genetic modifiers of the insulin resistance phenotype in mice.Semantic proximity Read ↗

Genetic analysis of obese diabetes in the TSOD mouse.Semantic proximity Read ↗

Identification of Interactive Loci Linked to Insulin and Leptin in Mice With Genetic Insulin ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.