Article
Genetic analysis of non-insulin-dependent diabetes mellitus in KK and KK-Ay mice.
European journal of endocrinology - 1 Dec 1998
Suto J, Matsuura S, Imamura K, Yamanaka H, Sekikawa K
Abstract excerpt
The KK mouse is considered suitable as a polygenic model for human non-insulin-dependent diabetes mellitus. To identify the quantitative trait loci (QTLs) responsible for hyperglycemia and impaired glucose tolerance in KK mice, linkage analysis using 97 microsatellite markers was carried out in a 192 F2 progeny, comprising 93 mice with the a/a genotype at the agouti locus (chromosome 2) and 99 mice with the Ay/a...
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