Article
Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 May 2005
Shink Eric, Harvey Mario, Tremblay Monique, Gagné Bernard, Belleau Pascal, Raymond Catherine, Labbé Michel, Dubé Marie-Pierre, Lafrenière Ronald G, Barden Nicholas
Abstract excerpt
Previous results from our genetic analyses using pedigrees from a French Canadian population suggested that the interval delimited by markers D12S86 and D12S378 on chromosome 12 was the most probable genomic region to contain a susceptibility gene for affective disorders. Here we present a more detailed genetic analysis of a 7.7 Mb genomic region located on 12q24.31. This region was saturated with 20...
Topics
- Alleles
- Bipolar Disorder
- Chromatography, High Pressure Liquid
- Chromosomes, Human, Pair 12
- DNA
- DNA Mutational Analysis
- Family Health
- Female
- Gene Frequency