Article
Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees.
PLoS pathogens - 1 Jan 2012
Morin Trevor J, Broering Teresa J, Leav Brett A, Blair Barbra M, Rowley Kirk J, Boucher Elisabeth N, Wang Yang, Cheslock Peter S, Knauber Michael, Olsen David B, Ludmerer Steve W, Szabo Gyongyi, Finberg Robert W, Purcell Robert H, Lanford Robert E, Ambrosino Donna M, Molrine Deborah C, Babcock Gregory J
Abstract excerpt
Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there is an urgent need to develop therapies to reduce rates of HCV infection of transplanted livers. Approved therapeutics for HCV are poorly tolerated and are of limited efficacy in this patient population. Human monoclonal antibody HCV1 recognizes a highly-conserved linear epitope of the HCV E2 envelope glycoprotein (amino acids...
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