Article

Neuron-intrinsic NF-κB Signaling Mediates Reovirus Virulence

2020-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Pathological effects of apoptosis associated with viral infections of the central nervous system are an important cause of morbidity and mortality. Reovirus is a neurotropic virus that causes apoptosis in neurons, leading to lethal encephalitis in newborn mice. Reovirus-induced encephalitis is diminished in mice with germline ablation of NF-κB subunit p50. It is not known whether the pro-apoptot...

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Literature Corpus work: 9d74e697-d206-5b9d-bb3a-20c099add24e
DOI: 10.1101/2020.08.05.238220

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