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Article

Role of a cytotoxic-T-lymphocyte epitope-defined, alternative gag open reading frame in the pathogenesis of a murine retrovirus-induced immunodeficiency syndrome.

Journal of virology - 1 Apr 2005

Gaur Arti, Green William R

Abstract excerpt

LP-BM5 murine leukemia virus-infected C57BL/6 mice develop profound immunodeficiency and B-cell lymphomas. The LP-BM5 complex contains a mixture of defective (BM5def) and replication-competent helper viruses among which BM5def is the primary causative agent of disease. The BM5def primary open reading frame (ORF1) encodes the single gag precursor protein (Pr60gag). Our lab has recently demonstrated that a novel...

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Identifiers

PMID: 15767431
DOI: 10.1128/JVI.79.7.4308-4315.2005
PMCID: PMC1061551

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Source receipt: pubmed, retrieved 7 Sept 2026.

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