Article
Founder effect for the highly prevalent R337H mutation of tumor suppressor p53 in Brazilian patients with adrenocortical tumors.
Arquivos brasileiros de endocrinologia e metabologia - 1 Oct 2004
Pinto Emilia M, Billerbeck Ana Elisa C, Villares Maria Candida B F, Domenice Sorahia, Mendonça Berenice B, Latronico Ana Claudia
Abstract excerpt
The incidence of adrenocortical tumors in children from the Southern region of Brazil is higher than in other parts of the world. This fact has been related to the identification of an inherited missense mutation of the p53 (R337H) at high frequency (78-97%) in Brazilian children with adrenocortical tumors. Given the high frequency of this germline mutation in the Brazilian population, it is very likely that the...
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