Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple TP53 p.R337H haplotypes and implications for tumor susceptibility

4 Oct 2023

Abstract excerpt

The germline TP53 p.R337H mutation is reported as the most common germline TP53 variant. It exists at a remarkably high frequency in the population of southeast Brazil as founder mutation in two distinct haplotypes with the most frequent co-segregating with the p.E134∗ variant of the XAF1 tumor suppressor and an increased cancer risk. Founder mutations demonstrate linkage disequilibrium with neighboring genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Molecular Biology Techniques and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37794678
DOI: 10.1016/j.xhgg.2023.100244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple TP53 p.R337H haplotypes and implications for tumor susceptibilityPMID 37794678Read ↗

Detailed haplotype analysis at the TP53 locus in p.R337H mutation carriers in the population of Southern Brazil: evidence for a founder effect.Semantic proximity Read ↗

What 20 years of research has taught us about the TP53 p.R337H mutation.Semantic proximity Read ↗

Founder effect for the highly prevalent R337H mutation of tumor suppressor p53 in Brazilian patients with adrenocortical tumors.Semantic proximity Read ↗

Reconstructing the Origin and Demographic Expansion of the TP53 p.R337H Founder Variant in Brazil.Semantic proximity Read ↗

European Colonial Echoes in Cancer Risk: Lessons from the TP53 p.R337H Founder Variant in Brazil.Semantic proximity Read ↗

Detection of R337H, a germline TP53 mutation predisposing to multiple cancers, in asymptomatic women participating in a breast cancer screening program in Southern Brazil.Semantic proximity Read ↗

XAF1 as a modifier of p53 function and cancer susceptibilitySemantic proximity Read ↗

The Inherited p53 Mutation in the Brazilian Population.Semantic proximity Read ↗

Tumor Spectrum and Temporal Cancer Trends in adult carriers of Li-Fraumeni syndrome: Implications for Personalized Screening Strategies in<i>TP53</i>R337H carriersSemantic proximity Read ↗

Association of the germline TP53 R337H mutation with breast cancer in southern Brazil.Semantic proximity Read ↗

[Brazilian story of the R337H p53 mutation].Semantic proximity Read ↗

TP53 p.R337H Germline Variant among Women at Risk of Hereditary Breast Cancer in a Public Health System of Midwest Brazil.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.