Article
Contribution of the TP53 R337H mutation to the cancer burden in southern Brazil: Insights from the study of 55 families of children with adrenocortical tumors.
Cancer - 15 Aug 2017
Mastellaro Maria J, Seidinger Ana L, Kang Guolian, Abrahão Renata, Miranda Eliana C M, Pounds Stanley B, Cardinalli Izilda A, Aguiar Simone S, Figueiredo Bonald C, Rodriguez-Galindo Carlos, Brandalise Silvia R, Yunes José A, Barros-Filho Antônio de A, Ribeiro Raul C
Abstract excerpt
BACKGROUND: The tumor protein p53 (TP53) arginine-to-histidine mutation at codon 337 (R337H) predisposes children to adrenocortical tumors (ACTs) and, rarely, to other childhood tumors, but its impact on adult cancer remains undetermined. The objective of this study was to investigate the frequency and types of cancer in relatives of children with ACT who carry the TP53 R337H mutation. METHODS: TP53 R337H testing...
Topics
- Adolescent
- Adrenal Cortex Neoplasms
- Adult
- Brazil
- Breast Neoplasms
- Child
- Child, Preschool
- Family
- Female
- Genetic Predisposition to Disease