Article
What 20 years of research has taught us about the TP53 p.R337H mutation.
Cancer - 1 Nov 2020
Pinto Emilia Modolo, Zambetti Gerard P
Abstract excerpt
The p53 tumor suppressor transcriptionally regulates a myriad of genes involved in cell cycle control, DNA repair, cell survival, and cell metabolism and represents one of the most well-studied inhibitors of tumorigenesis. Since the discovery of TP53 in 1979, somatic mutations have been shown to be extremely common; more than 50% of human cancers carry loss-of-function mutations in TP53. Inherited or germline...
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