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Article

Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?

The Lancet. Oncology - 1 Sept 2009

Achatz Maria Isabel Waddington, Hainaut Pierre, Ashton-Prolla Patricia

Abstract excerpt

The unusually high population frequency of a germline TP53 mutation (R337H) predisposing to early cancer has led to mass newborn testing for this mutation in the State of Paraná, southern Brazil. Newborn screening for inherited cancer risk is complex and controversial. In this paper, we discuss the justifications for this screening by considering the medical and scientific evidence for this mutation. R337H has...

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Identifiers

PMID: 19717094
DOI: 10.1016/S1470-2045(09)70089-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?PMID 19717094Read ↗

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The R337H mutation in TP53 and breast cancer in BrazilSemantic proximity Read ↗

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