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A Mycobacterium avium PPE gene is associated with the ability of the bacterium to grow in macrophages and virulence in mice

13 Dec 2004

Abstract excerpt

PPE and PE gene families, which encode numerous proteins of unknown function, account for 10% of Mycobacterium tuberculosis genome. Mycobacterium avium genome has similar PPE and PE gene families. Using a temperature-sensitive phage phAE94 transposon mutagenesis system, a M. avium transposon library was created in the strain MAC109. Screening of individual mutants in human U937 macrophages for the ability to...

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PMID: 15760454
DOI: 10.1111/j.1462-5822.2004.00484.x

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