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Article

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Laencina Laura, Dubois Violaine, Le Moigne Vincent, Viljoen Albertus, Majlessi Laleh, Pritchard Justin, Bernut Audrey, Piel Laura, Roux Anne-Laure, Gaillard Jean-Louis, Lombard Bérengère, Loew Damarys, Rubin Eric J, Brosch Roland, Kremer Laurent, Herrmann Jean-Louis, Girard-Misguich Fabienne

Abstract excerpt

Mycobacterium abscessus, a rapidly growing mycobacterium (RGM) and an opportunistic human pathogen, is responsible for a wide spectrum of clinical manifestations ranging from pulmonary to skin and soft tissue infections. This intracellular organism can resist the bactericidal defense mechanisms of amoebae and macrophages, an ability that has not been observed in other RGM. M. abscessus can up-regulate several...

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PMID: 29343644
DOI: 10.1073/pnas.1713195115
PMCID: PMC5798338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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