Article
ICAM G241A polymorphism and soluble ICAM-1 serum levels: evidence for an active immune process in schizophrenia.
Neuroimmunomodulation - 1 Jan 2005
Kronig Holger, Riedel Michael, Schwarz Markus J, Strassnig Martin, Moller Hans-Jurgen, Ackenheil Manfred, Muller Norbert
Abstract excerpt
OBJECTIVES: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism (SNP) of the ICAM-1 gene was described at position 241. The G-->A SNP results in a nonsynonymous amino acid exchange of the ICAM-1 protein, and the A allele was shown to be also associated with several immunological disorders like...
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