Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early Genetic Events Provide the Basis for a Clinical Classification of Multiple Myeloma

1 Jan 2005

Abstract excerpt

Multiple myeloma is a tumor of somatically mutated, isotype-switched plasma cells that accumulate in the bone marrow leading to bone destruction and bone marrow failure. The germinal center processes of somatic hypermutation and switch recombination are implicated in the development of recurrent immunoglobulin gene translocations in 40% of patients. These affect five loci: 11q13, 6p21, 4p16, 16q23 and 20q11,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16304402
DOI: 10.1182/asheducation-2005.1.346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early Genetic Events Provide the Basis for a Clinical Classification of Multiple MyelomaPMID 16304402Read ↗

Molecular pathogenesis and a consequent classification of multiple myeloma.Semantic proximity Read ↗

Molecular Pathogenesis of Multiple Myeloma: Clinical Implications.Semantic proximity Read ↗

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.Semantic proximity Read ↗

Genetic and molecular mechanisms in multiple myeloma: a route to better understand disease pathogenesis and heterogeneitySemantic proximity Read ↗

The Genetic Architecture of Multiple MyelomaSemantic proximity Read ↗

Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple MyelomaSemantic proximity Read ↗

Advances in the pathogenesis and diagnosis of multiple myeloma.Semantic proximity Read ↗

A Comprehensive Review of the Genomics of Multiple Myeloma: Evolutionary Trajectories, Gene Expression Profiling, and Emerging Therapeutics.Semantic proximity Read ↗

The multiple myelomas — current concepts in cytogenetic classification and therapySemantic proximity Read ↗

Molecular aspects of multiple myelomaSemantic proximity Read ↗

Advances in biology of multiple myeloma: clinical applicationsSemantic proximity Read ↗

Molecular pathogenesis of multiple myeloma: basic and clinical updatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.