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Article

Antidiabetic thiazolidinediones induce ductal differentiation but not apoptosis in pancreatic cancer cells.

World journal of gastroenterology - 28 Feb 2005

Ceni Elisabetta, Mello Tommaso, Tarocchi Mirko, Crabb David-W, Caldini Anna, Invernizzi Pietro, Surrenti Calogero, Milani Stefano, Galli Andrea

Abstract excerpt

AIM: Thiazolidinediones (TZD) are a new class of oral antidiabetic drugs that have been shown to inhibit growth of same epithelial cancer cells. Although TZD were found to be ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), the mechanism by which TZD exert their anticancer effect is presently unclear. In this study, we analyzed the mechanism by which TZD inhibit growth of human pancreatic...

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Identifiers

PMID: 15754392
DOI: 10.3748/wjg.v11.i8.1122
PMCID: PMC4250701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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