Article
Peroxisome proliferator-activated receptor gamma (PPARgamma) and colorectal carcinogenesis.
Journal of cancer research and clinical oncology - 1 Dec 2007
Voutsadakis Ioannis A
Abstract excerpt
Peroxisome proliferator-activated receptor gamma (PPARgamma) a member of the nuclear transcription factor superfamily is playing a role in colon carcinogenesis. Although not all in vivo models agree, PPARgamma seems to have suppressive effects in this process favoring apoptosis and inhibiting the cell cycle by inducing expression of apoptosis and senescence proteins. With the recent discovery that anti-diabetic...
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