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Article

Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

The Journal of biological chemistry - 25 Feb 2005

Lu Meiling, Kwan Toni, Yu Chunjiang, Chen Feng, Freedman Bethany, Schafer Jennifer M, Lee Eun-Jig, Jameson J Larry, Jordan V Craig, Cryns Vincent L

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising cancer therapy that preferentially induces apoptosis in cancer cells. However, many neoplasms are resistant to TRAIL by mechanisms that are poorly understood. Here we demonstrate that human breast cancer cells, but not...

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Identifiers

PMID: 15569667
DOI: 10.1074/jbc.M411519200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569667-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.PMID 15569667Read ↗

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