Article
3,5,3'-Triiodo-L-thyronine enhances the differentiation of a human pancreatic duct cell line (hPANC-1) towards a beta-cell-Like phenotype.
Journal of cellular physiology - 1 Jul 2005
Misiti Silvia, Anastasi Emanuela, Sciacchitano Salvatore, Verga Falzacappa Cecilia, Panacchia Laura, Bucci Barbara, Khouri Daniele, D'Acquarica Ilaria, Brunetti Ercole, Di Mario Umberto, Toscano Vincenzo, Perfetti Riccardo
Abstract excerpt
The thyroid hormone, 3,5,3'-Triiodo-L-thyronine (T3), is essential for growth, differentiation, and regulation of metabolic functions in multicellular organisms, although the specific mechanisms of this control are still unknown. In this study, treatment of a human pancreatic duct cell line (hPANC-1) with T3 blocks cell growth by an increase of cells in G(0)/G(1) cell cycle phase and enhances morphological and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.