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Article

The Effects of HER2 Alterations in EGFR Mutant Non-small Cell Lung Cancer.

Clinical lung cancer - 1 Jan 2022

Nagasaka Misako, Singh Vijendra, Baca Yasmine, Sukari Ammar, Kim Chul, Mamdani Hirva, Spira Alexander I, Uprety Dipesh, Bepler Gerold, Kim Edward S, Raez Luis E, Pai Sachin Gopalkrishna, Ikpeazu Chukwuemeka, Oberley Matthew, Feldman Rebecca, Xiu Joanne, Korn W Michael, Wozniak Antoinette J, Borghaei Hossein, Liu Stephen V

Abstract excerpt

BACKGROUND: HER2 alteration (mutation and/or amplification) is associated with poor survival in NSCLC and can mediate resistance to EGFR tyrosine kinase inhibitors. METHODS: We retrospectively analyzed de-identified molecular information from 12,946 NSCLC samples that underwent next-generation sequencing (NGS) with Caris Life Sciences. The objectives were to determine the prevalence and type of HER2 alterations...

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PMID: 34801409
DOI: 10.1016/j.cllc.2021.08.012

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