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Article

Transcriptome profiling of equine vitamin E deficient neuroaxonal dystrophy identifies upregulation of liver X receptor target genes.

Free radical biology & medicine - 1 Dec 2016

Finno Carrie J, Bordbari Matthew H, Valberg Stephanie J, Lee David, Herron Josi, Hines Kelly, Monsour Tamer, Scott Erica, Bannasch Danika L, Mickelson James, Xu Libin

Abstract excerpt

Specific spontaneous heritable neurodegenerative diseases have been associated with lower serum and cerebrospinal fluid α-tocopherol (α-TOH) concentrations. Equine neuroaxonal dystrophy (eNAD) has similar histologic lesions to human ataxia with vitamin E deficiency caused by mutations in the α-TOH transfer protein gene (TTPA). Mutations in TTPA are not present with eNAD and the molecular basis remains unknown....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27751910
DOI: 10.1016/j.freeradbiomed.2016.10.009
PMCID: PMC5154892

Genes

APOE
TTPA
ABCA1
PLTP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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