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Article

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

15 Oct 2012

Abstract excerpt

The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring TTP's significance during fetal development. TTP and vitamin E are...

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PMID: 23077608
DOI: 10.1371/journal.pone.0047402

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