Article
Evidence for non-enzymatic glycosylation of Escherichia coli chromosomal DNA.
Molecular microbiology - 1 Mar 2005
Mironova Roumyana, Niwa Toshimitsu, Handzhiyski Yordan, Sredovska Angelina, Ivanov Ivan
Abstract excerpt
We have recently shown that the process of non-enzymatic glycosylation (glycation) takes place in Escherichia coli under physiological conditions and affects both recombinant and endogenous bacterial proteins. In this study, we further demonstrate that E. coli chromosomal DNA is also subjected to glycation under physiological growth conditions. The E. coli DNA accumulates early glycation (Amadori) products as...
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