Article
In vitro and in vivo reactions of nucleic acids with reducing sugars.
Mutation research - 1 May 1990
Lee A T, Cerami A
Abstract excerpt
Reducing sugars such as glucose and glucose 6-phosphate have been shown to nonenzymatically react with the amino groups of proteins. The modification of proteins by reducing sugars can alter both physical characteristics and biological functions. Analogous to the reaction observed with proteins, the amino groups of DNA bases are also able to react nonenzymatically with reducing sugars. The modifications of DNA by...
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