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Article

The S68G polymorphism is a compensatory mutation associated with the drug resistance mutation K65R in CRF01_AE strains.

BMC infectious diseases - 11 Feb 2020

Li Shengjia, Ouyang Jinming, Zhao Bin, An Minghui, Wang Lin, Ding Haibo, Zhang Min, Han Xiaoxu

Abstract excerpt

BACKGROUND: The rate of S68G mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase has increased and is closely related to the K65R mutation among CRF01_AE-infected patients who failed treatment. We aimed to explore the temporal association of S68G and K65R mutations and disclose the role of the former on susceptibility to nucleotide/nucleoside reverse transcriptase inhibitor (NRTI) and...

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Identifiers

PMID: 32046664
DOI: 10.1186/s12879-020-4836-z
PMCID: PMC7014709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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