Article

A genetic screen to identify deubiquitinases as regulators of IRF7

2025-09-15

Abstract excerpt

Virus infection rapidly induces the production and secretion of interferons (IFNs), amplifying antiviral responses in infected and neighboring uninfected cells. IFN regulatory factor 7 (IRF7), the ‘master transcription factor,’ is pivotal in IFN induction, particularly in myeloid cells. Ubiquitination of IRF7 is essential for its transcriptional activation; however, the underlying molecular mechanisms remain poorl...

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Literature Corpus work: 6d98caa5-9336-5c65-870c-253c70f436d7
DOI: 10.1101/2025.09.09.675186

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