Article
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
Heart rhythm - 1 Oct 2012
Sinner Moritz F, Porthan Kimmo, Noseworthy Peter A, Havulinna Aki S, Tikkanen Jani T, Müller-Nurasyid Martina, Peloso Gina, Ulivi Sheila, Beckmann Britt Maria, Brockhaus A Catharina, Cooper Rebecca R, Gasparini Paolo, Hengstenberg Christian, Hwang Shih-Jen, Iorio Annamaria, Junttila M Juhani, Klopp Norman, Kähönen Mika, Laaksonen Maarit A, Lehtimäki Terho, Lichtner Peter, Lyytikäinen Leo-Pekka, Martens Eimo, Meisinger Christa, Meitinger Thomas, Merchant Faisal M, Nieminen Markku S, Peters Annette, Pietilä Arto, Perz Siegfried, Oikarinen Lasse, Raitakari Olli, Reinhard Wibke, Silander Kaisa, Thorand Barbara, Wichmann H-Erich, Sinagra Gianfranco, Viikari Jorma, O'Donnell Christopher J, Ellinor Patrick T, Huikuri Heikki V, Kääb Stefan, Newton-Cheh Christopher, Salomaa Veikko
Abstract excerpt
BACKGROUND: The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases. OBJECTIVE: To conduct a meta-analysis of genome-wide association studies to identify common genetic variants influencing ERP. METHODS: We ascertained ERP on the basis of electrocardiograms in 3 large community-based cohorts from...
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