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Article

Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation.

Current biology : CB - 22 Aug 2006

Bidère Nicolas, Snow Andrew L, Sakai Keiko, Zheng Lixin, Lenardo Michael J

Abstract excerpt

Triggering of lymphocyte antigen receptors is the critical first step in the adaptive immune response against pathogens. T cell receptor (TCR) ligation assembles a large membrane signalosome, culminating in NF-kappaB activation [1,2]. Recently, caspase-8 was found to play a surprisingly prominent role in lymphocyte activation in addition to its well-known role in apoptosis [3]. Caspase-8 is activated after TCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16920630
DOI: 10.1016/j.cub.2006.06.062

Genes

TRAF6
BCL10
MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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