Article
Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2005
Gu Jian, Zhao Hua, Dinney Colin P, Zhu Yong, Leibovici Dan, Bermejo Carlos E, Grossman H Barton, Wu Xifeng
Abstract excerpt
PURPOSE: Interindividual differences in DNA repair capacity not only modify individual susceptibility to carcinogenesis, but also affect individual response to cancer treatment. Nucleotide excision repair (NER) is one of the major DNA repair pathways in mammalian cells involved in the removal of a wide variety of DNA lesions. Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome...
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