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Article

TRAF2 plays a key, nonredundant role in LIGHT-lymphotoxin beta receptor signaling.

Molecular and cellular biology - 1 Mar 2005

Kim You-Sun, Nedospasov Sergei A, Liu Zheng-Gang

Abstract excerpt

LIGHT is a member of the tumor necrosis factor (TNF) superfamily, and its function is mediated by at least two receptors, including lymphotoxin beta receptor (LTbetaR) and herpes simplex virus entry mediator. However, the molecular mechanism of LIGHT signaling mediated by LTbetaR has not been clearly defined. In this report, we demonstrate that TRAF2 is critical for LIGHT- and LTbetaR-mediated activation of both...

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Source

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Identifiers

PMID: 15743811
DOI: 10.1128/MCB.25.6.2130-2137.2005
PMCID: PMC1061604

Genes

TRAF2
TNF
TRAF3
TRAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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