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Article

Artificial zinc finger fusions targeting Sp1-binding sites and the trans-activator-responsive element potently repress transcription and replication of HIV-1.

The Journal of biological chemistry - 3 Jun 2005

Kim Yeon-Soo, Kim Jung-Min, Jung Deug-Lim, Kang Jae-Eun, Lee Sukyung, Kim Jin Soo, Seol Wongi, Shin Hyun-Chul, Kwon Heung Sun, Van Lint Carine, Hernandez Nouria, Hur Man-Wook

Abstract excerpt

Tat activates transcription by interacting with Sp1, NF-kappaB, positive transcription elongation factor b, and trans-activator-responsive element (TAR). Tat and Sp1 play major roles in transcription by protein-protein interactions at human immunodeficiency virus, type 1 (HIV-1) long terminal repeat. Sp1 activates transcription by interacting with cyclin T1 in the absence of Tat. To disrupt the transcription...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15743774
DOI: 10.1074/jbc.M414136200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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